Patient's Education Portal
Anaphylaxis: Recognition & Emergency Response
Anaphylaxis is a serious, rapid-onset allergic reaction caused by an IgE-mediated response that can cause death without prompt treatment.
Immediate Attention Required
ANAPHYLAXIS IS A MEDICAL EMERGENCY. Any delay in recognition or treatment can result in a fatal outcome due to airway obstruction or vascular collapse.
Overview & Pathology
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. It is a condition caused by an IgE-mediated reaction. Delays in recognizing initial signs and symptoms can result in a fatal outcome due to airway obstruction or vascular collapse.
Triggers & Common Causes
Common triggers that can induce a severe anaphylactic reaction include:
- Food: Peanuts, tree nuts, milk, fish, and shellfish (although any food can cause a reaction).
- Medication: Various prescription and over-the-counter drugs.
- Insect Stings: Yellow jackets, honeybees, wasps, hornets, and fire ants.
- Latex: Natural rubber products such as condoms or latex gloves.
Treatment & Medical Management
When exposed to a known allergen, involvement of any two systems of the body necessitates immediate treatment with epinephrine.
Medications for Anaphylaxis:
- Epinephrine: Epinephrine is the only medication that can reverse severe anaphylactic symptoms. It is available by prescription.
- Antihistamines: Used as secondary treatment to relieve itching and dermatologic symptoms.
- Steroids: Steroids are often given in an attempt to protect against the “late” reaction that can occur several hours after the allergic reaction. Steroids do not reverse acute symptoms of anaphylaxis; their effects may take hours. For some patients, particularly those with asthma, this late reaction could be even more severe than the initial reaction.
Indications & Target Symptoms
Skin / Cutaneous
- Hives (Urticaria)
- Eczema flare
- Itchy red rash
- Flush
- Pruritus
- Angioedema
Respiratory System
- Runny nose & sneezing
- Cough
- Tightness of chest
- Wheezing
- Shortness of breath
- Upper or lower airway obstruction
Gastrointestinal System
- Cramps
- Nausea
- Vomiting
- Diarrhea
Cardiovascular & Systemic
- Drop in blood pressure
- Fainting (syncope or presyncopal symptoms)
- Watery eyes
- Itching or swelling of lips, tongue, or throat
- Change in voice
- Difficulty swallowing
Treatment Phases & Course
Acute Emergency Phase
Immediate administration of Epinephrine upon multi-system involvement or exposure to a known critical trigger to reverse severe airway or vascular collapse.
Late-Phase Protection
Administration of steroids and secondary antihistamines to alleviate cutaneous symptoms and guard against severe late-phase allergic recurrences hours after initial onset.